There are more than 100 million adults with diabetes or prediabetes in the United States. Learn about how you can take Janumet to fight type 2 diabetes.

Using this drug with proper diet and exercise can drastically improve your health.

Here’s what you need to know about taking Janumet:

How Janumet Works

What is Janumet? Janumet combines the power of 2 medications: sitagliptin/Januvia and metformin.

Sitagliptin increases your body’s level of incretins. Incretins control blood sugar by increasing insulin release, especially after you eat.

Metformin helps restore your body’s response to the insulin you produce. This drug also decreases how much sugar your liver makes and intestines absorb.

This drug helps your pancreas create more insulin. Your body uses insulin more efficiently while on Janumet. Using this drug also decreases any excess sugar your liver makes.

Taking this combination drug also controls blood sugar levels throughout the day, including after meals.

Side Effects

While taking Janumet, you might experience upset stomach, nausea, vomiting, weakness, headache, constipation, diarrhea, joint or muscle pain, or cold symptoms like sneezing, sore throat, or stuffy nose.

You might also experience a metallic taste in your mouth.

If these effects continue or worsen, you must tell your pharmacist and doctor immediately.

This drug is not associated with weight gain or low blood sugar (hypoglycemia). However, low blood sugar can occur if Janumet is taken with other anti-diabetic medications.

The metformin in this medication can cause lactic acidosis, a build-up of lactic acid in the body. This condition can be fatal and requires emergency medical attention. Contact your doctor if you experience muscle pain or weakness, numb or cold feelings in your arms and legs, trouble breathing, slow or irregular heartbeat, dizziness, and/or extreme fatigue.

Taking metformin for diabetes also promotes ovulation and increases your chance of getting pregnant.

You might see something that resembles the Janumet tablet in your stool. If this happens several times, notify your doctor.

Call your doctor if you experience pancreatitis, urinating infrequently or not at all, shortness of breath (especially from mild exertion), or a severe skin reaction. This severe skin reaction is characterized by a red or purple rash accompanied by sore throat, fever, swelling in the face or tongue, skin pain, and burning in the eyes.


You’re supposed to take Janumet twice daily with meals. Each tablet contains 50 mg sitagliptin and 500 mg metformin hydrochloride or 50 mg sitagliptin and 1000 mg metformin.

The once-daily pills (Janumet XR) contain sitagliptin and extended-release metformin.

The maximum recommended dosage of sitagliptin is 100 mg. For metformin, it’s 2,000 mg.

It’s highly recommended to take this medication at night with food. This will reduce your chance of getting an upset stomach.

Make sure you consume the tablets whole. Do not break the tablets up as this will disturb the distribution of the medication.

When overdosing, you might experience passing out or trouble breathing. Seek emergency healthcare immediately if this happens.

Take Control of Your Health

Nearly 1 out of 10 adults in the United States suffer from diabetes. Type 2 diabetes is no match for Janumet.

Embrace your health and learn about how medications affect your body. It’s vital to take care of yourself!